The well-known function of melatonin is to improve sleep quality (dosage 0.1 ~ 0.3mg), shorten the awakening time and sleep time before sleep, improve sleep quality, significantly reduce the number of awakenings during sleep, shorten the light sleep stage, prolong the deep sleep stage, and lower the wake-up threshold in the next morning. It has strong time difference adjustment function.
The biggest characteristic of melatonin is that it is the strongest endogenous free radical scavenger found so far. The basic function of melatonin is to participate in the antioxidant system and prevent cells from oxidative damage. In this regard, its efficacy exceeds all known substances in the body. The latest research has proved that MT is the commander-in-chief of endocrine, which controls the activities of various endocrine glands in the body. It has the following functions:
Prevention of pathological changes
Because MT is easy to enter cells, it can be used to protect nuclear DNA. If DNA is damaged, it can lead to cancer.
If there is enough Mel in the blood, it is not easy to get cancer.
Adjust circadian rhythm
The secretion of melatonin has a circadian rhythm. After nightfall, the light stimulation weakens, the enzyme activity of melatonin synthesis in the pineal gland increases, and the secretion level of melatonin in the body increases correspondingly, reaching the peak at 2-3 a.m. the level of melatonin at night directly affects the quality of sleep. With the growth of age, the pineal gland shrinks until calcification, resulting in the weakening or disappearance of the rhythm of the biological clock, Especially after 35 years old, the level of melatonin secreted by the body decreased significantly, with an average decrease of 10-15% every 10 years, leading to sleep disorders and a series of functional disorders. The decrease of melatonin level and sleep is one of the important signs of human brain aging. Therefore, the supplement of melatonin in vitro can maintain the melatonin level in the body in a young state, adjust and restore the circadian rhythm, which can not only deepen sleep, but also improve the quality of life, To improve the quality of sleep, it is more important to improve the functional state of the whole body, improve the quality of life and delay the process of aging.
Melatonin is a kind of hormone that can induce natural sleep. It can overcome sleep disorder and improve sleep quality by regulating natural sleep. The biggest difference between melatonin and other sleeping pills is that melatonin has no addiction and no obvious side effects. Taking 1-2 tablets (about 1.5-3mg melatonin) before going to bed at night can generally produce drowsiness within 20 to 30 minutes, but melatonin will automatically lose efficacy after dawn in the morning, After getting up, there will be no feeling of being tired, sleepy and unable to wake up.
The pineal gland of the elderly gradually shrinks and the secretion of Mel correspondingly decreases. The lack of Mel required by various organs in the body leads to aging and diseases. Scientists call the pineal gland the body’s “aging clock.”. We supplement Mel from the body, and then we can turn back the aging clock. In the autumn of 1985, scientists used 19 month old mice (65 years old in humans). The living conditions and food of group A and group B were exactly the same, except that Mel was added to the drinking water of group A at night, and no substance was added to the drinking water of group B. At first, there was no difference between the two groups. Gradually, there was an amazing difference. The mice in control group B were aging obviously: muscle mass disappeared, bald patches covered the skin, dyspepsia and cataract in eyes. All in all, the mice in this group were old and dying. It’s amazing that the group A mice who drink Mel water every night play with their grandchildren. The whole body has thick thick hair, radiant, good digestion, and no cataract in the eyes. As for their average life span, the mice in group B all suffered a maximum of 24 months (equivalent to 75 years old in humans); The average life span of mice in group A is 30 months (100 years of human life).
Regulatory effect on central nervous system
A large number of clinical and experimental studies have shown that melatonin, as an endogenous neuroendocrine hormone, has direct and indirect physiological regulation on the central nervous system, has therapeutic effect on sleep disorders, depression and mental diseases, and has protective effect on nerve cells. For example, melatonin has a sedative effect, can also treat depression and psychosis, can protect the nerve, can relieve pain, regulate the release of hormones from the hypothalamus, and so on.
Regulation of immune system
Neuroendocrine and immune system are interrelated. Immune system and its products can change the function of neuroendocrine. Neuroendocrine signals also affect the immune function. In recent ten years, the regulatory effect of melatonin on the immune system has attracted widespread attention. Studies at home and abroad show that it not only affects the growth and development of immune organs, but also regulates humoral and cellular immunity, as well as cytokines. For example, melatonin can regulate cellular and humoral immunity, as well as the activities of a variety of cytokines.
Regulation of cardiovascular system
Mel is a kind of light signal with many functions. Through the change of its secretion, it can transmit the information of environmental light cycle to the relevant tissues in the body, so that their functional activities can adapt to the changes of the outside world. Therefore, the level of serum melatonin secretion can reflect the corresponding time of the day and the corresponding season of the year. The circadian and seasonal rhythms of organisms are closely related to the periodic changes of energy and oxygen supply of cardiovascular system and respiratory system. The function of vascular system has obvious circadian and seasonal rhythm, including blood pressure, heart rate, cardiac output, renin angiotensin aldosterone, etc. Epidemiological studies found that the incidence of myocardial infarction and ischemic heart disease increased about in the morning, suggesting that the onset of time-dependent. In addition, blood pressure and catecholamine decreased at night. Mel is mainly secreted at night, affecting a variety of endocrine and biological functions. The relationship between Mel and circulatory system can be confirmed by the following experimental results: the increase of Mel secretion at night is negatively correlated with the decrease of cardiovascular activity; Melatonin in pineal gland can prevent cardiac arrhythmia caused by ischemia-reperfusion injury, affect blood pressure control, regulate cerebral blood flow, and regulate the response of peripheral arteries to norepinephrine. Therefore, Mel can regulate the cardiovascular system.
In addition, melatonin also regulates the respiratory system, digestive system and urinary system.
Post time: Jun-22-2021